scholarly journals Ectopic production of human chorionic gonadotrophin-like material by breast cancer

Cancer ◽  
1984 ◽  
Vol 53 (4) ◽  
pp. 957-962 ◽  
Author(s):  
Jorge C. M. P. Monteiro ◽  
Keith M. Ferguson ◽  
J. Alan McKinna ◽  
W. Peter Greening ◽  
Alexander M. Neville
Keyword(s):  
Breast Cancer ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Ectopic Production

scholarly journals Ectopic Production of Human Chorionic Gonadotrophin by Human Breast Tumours

1974 ◽  
Vol 30 (6) ◽  
pp. 566-570 ◽  
Author(s):  
N A Sheth ◽  
J N Saruiya ◽  
K J Ranadive ◽  
A R Sheth
Keyword(s):  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Human Breast ◽  
Breast Tumours ◽  
Ectopic Production

Enhancement of ectopic β-human chorionic gonadotrophin expression by interferon-α

1989 ◽  
Vol 123 (3) ◽  
pp. 501-507 ◽  
Author(s):  
R. K. Iles ◽  
T. Chard
Keyword(s):  
Cell Line ◽  
Bladder Tumour ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Interferon Α ◽  
Reproductive Endocrine ◽  
Hcg Secretion ◽  
Ectopic Production ◽  
Ifn Γ ◽  
Β Hcg

ABSTRACT Treatment of three β-human chorionic gonadotrophin (β-hCG)-expressing bladder tumour cell lines with interferon-α (IFN-α) (5000 U/per 106 cells) enhanced the rate of β-hCG secretion from 34·2 ±0·9 to 102·5 ± 0·1 mIU/106 cells per 72 h in cell line 5637; 111·15 ± 11·75 to 261·8± 51·75 mIU/106 cells per 72 h in cell line RT112 and 503·25 ± 28·55 to 1361·65± 110·3 mIU/106 cells per 72 h in cell line SCaBER. IFN-γ had no effect on the rate of β-hCG secretion. Both interferons reduced the growth rate of the cells: incorporation of radiolabelled thymidine was reduced by 15–45% in the presence of IFN-α and by 20–53% with IFN-γ. Enhancement of β-hCG secretion by IFN-α was dose-dependent over the range 5–50 000 U/106 cells. Analysis of cell cycle profiles by flow cytometry showed no increase in the proportion of cells in the G0G1 phase in cultures treated with IFN-α. The conceptus of some species produces substances which are either luteotrophic or anti-luteolytic. In sheep, the corpus luteum is maintained by ovine trophoblast protein-I, which has been shown to have structural homology with human IFN-α. In primates and a few other higher mammals, early pregnancy is maintained by chorionic gonadotrophin. IFN-α is also an early product of the human conceptus. We have now shown that IFN-α enhances the ectopic production of the β-subunit of hCG by bladder tumour cells. This study suggests a direct transcription/translational effect of this cytokine on the expression of a reproductive endocrine gene. Journal of Endocrinology (1989) 123, 501–507

scholarly journals Breast cancer with choriocarcinomatous and neuroendocrine features

2001 ◽  
Vol 119 (4) ◽  
pp. 154-155 ◽  
Author(s):  
Osvaldo Giannotti Filho ◽  
Luciana Nakao Odashiro Miiji ◽  
Marta Vainchenker ◽  
Ângela Navarro Gordan
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Giant Cells ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Axillary Lymph ◽  
Brazilian Woman ◽  
The Right

CONTEXT: Breast cancer may express the presence of b-human chorionic gonadotrophin in 12% to 18% of cases, using immunohistochemical reactions. Usually the tumors will show positivity in a few scattered cells. Breast cancer with choriocarcinomatous features, as reported by Saigo and Rosen, is a distinct variant of breast cancer. We report a case of breast cancer with choriocarcinomatous and neuroendocrine features. OBJECTIVE: This is a case report of an invasive ductal carcinoma of the breast with choriocarcinomatous and neuroendocrine features. DESIGN: Case Report. CASE REPORT: A 50-year-old Brazilian woman underwent surgery for a lump in the right breast, which had been first noticed about 3 months earlier. The surgery consisted of quadrantectomy followed by right mastectomy with ipsilateral axillary lymph node dissection. The specimen from the quadrantectomy revealed a 7 x 6.5 x 4.5 cm tumor. Histology of the lesion showed the presence of an invasive ductal carcinoma with areas of giant cells and intense atypia. The immunohistochemistry was positive in the pleomorphic areas for human chorionic gonadotrophin, while the less pleomorphic areas showed positivity for synaptophysin and chromogranin.

Amplification or rearrangement of the β-human chorionic gonadotrophin (β-hCG)—human LH gene cluster is not responsible for the ectopic production of β-hCG by bladder tumour cells

1989 ◽  
Vol 2 (2) ◽  
pp. 113-117 ◽  
Author(s):  
R. K. Iles ◽  
B. H. Czepulkowski ◽  
B. D. Young ◽  
T. Chard
Keyword(s):  
Gene Cluster ◽  
Genomic Dna ◽  
Bladder Tumour ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Chromosome 19 ◽  
Ectopic Production ◽  
Tumour Cell Lines ◽  
Altered Gene ◽  
Β Hcg

ABSTRACT The β-subunit of human chorionic gonadotrophin (hCG) is coded on chromosome 19 by the β-hCG-hLH gene cluster. Genomic DNA has been isolated from bladder tumour cell lines which ectopically express β-hCG. The β-hCG—hLH gene cluster was probed for possible rearrangement or amplification and cells karyotyped for chromosome 19 abnormalities. No rearrangement or amplification of the gene cluster and no consistent abnormalities of chromosome 19 were found. The expression of β-hCG by bladder tumours is therefore likely to be the result of altered gene regulation and not a rearrangement or amplification of this gene cluster.

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